Case report


Transdiscal Core Biopsy of Aortocaval Lymph Node: A Case Report

James Ryan LoftusVinit Khanna
Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642
Corresponding Author:
Corresponding Author

James Ryan Loftus

Imaging Sciences, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave Box 212, Rochester, New York, United States, 14642
E-mail: james_loftus@urmc.rochester.edu

DOI: 10.25259/AJIR-6-2017

ABSTRACT


The transdiscal approach has been described for nerve block and neurolysis of the hypogastric and celiac plexuses for chronic pain relief; however reports utilizing transdiscal approach for biopsy of aortocaval lymph nodes or other retroperitoneal masses are scarce. Traditional posterior paravertebral, lateral, or anterior approaches are often not technically feasible for core biopsy of aortocaval lesions due overlying bowel, organs, or vessels. In aortocaval or other retroperitoneal lesions inaccessible by traditional techniques the transdiscal method is invaluable in providing a linear approach that avoids the major vessels, organs, and bowel and allows for core biopsy. This case report demonstrates the use of transdiscal approach for core biopsy of aortocaval lesions otherwise inaccessible by traditional approaches.
Keywords: transdiscal approach, biopsy, aortocaval, retroperitoneal, lymph node

INTRODUCTION


The transdiscal approach has been extensively described in the anesthesiology literature for performing nerve block and neurolysis of the hypogastric and celiac plexuses for chronic pain relief; most commonly under computed tomography (CT) guidance with a 22G spinal needle.[1,2,3,4] Although well described in the anesthesiology literature, there is a paucity of studies in the radiology literature utilizing the transdiscal approach. Cazzato et al. described a case report where they utilized a CT-guided transdiscal approach with a 22G spinal needle to perform hydrodissection around a fluorodeoxyglucose-avid retrocrural lymph node abutting the aorta to facilitate cryoablation.[5] However, the literature describing the use of the transdiscal approach for biopsy is scarce, despite its hypothetical value in core biopsy of lymph nodes or other masses in the aortocaval region inaccessible by traditional interventional techniques due to bowel, organs, or major vessels. This report describes the successful utilization of the transdiscal approach for core biopsy of an aortocaval lymph node in a patient with a history of breast cancer.

CASE REPORT


A 48-year-old woman with a history of stage IIB (T2, N1a, and M0) estrogen and progesterone receptor positive, human epidermal growth factor receptor 2/proto-oncogene Neu (HER2/neu) positive, grade 3 infiltrating ductal carcinoma of the right breast, status post right mastectomy, and axillary lymph node dissection, was referred to the department of imaging sciences for biopsy of an enlarged aortocaval lymph node discovered on a CT of the abdomen and pelvis with contrast. Initially, the patient presented to their oncologist with sternal discomfort and underwent a bone scan with findings suggestive of but not definite for metastatic disease of the sternum. Following the bone scan, the oncologist chose to order CT scans of the chest and abdomen and pelvis with contrast to further workup for metastatic disease, the latter of which revealed the lymph node. Positron emission tomography-CT was not performed at the discretion of the oncologist. The oncologist then referred the patient to the department of imaging sciences for biopsy of the lymph node discovered on the CT of the abdomen and pelvis. Upon review of the CT images, the location of the lymph node made traditional posterior paravertebral, lateral, or anterior approaches too risky. A detailed examination of the images showed the enlarged 1.7 cm by 1.0 cm aortocaval lymph node at the level of the L2-L3 disc space, making the patient an ideal candidate for a core biopsy utilizing the transdiscal approach under CT guidance (Figure 1). Informed consent was obtained and the patient was scheduled to undergo the biopsy.
Fig1A.jpg Fig1B.jpg

Figure 1: A 48-year-old woman with a history of breast cancer presenting with sternal discomfort. In a work up for metastatic disease computed tomography (CT) of the abdomen and pelvis with contrast was performed. Axial (a) and sagittal (b) images from the original CT abdomen and pelvis with contrast showing the enlarged aortocaval lymph node (arrow) in plane with the L2-L3 disc space.

Fig1A.jpg
Fig1B.jpg

Figure 1: A 48-year-old woman with a history of breast cancer presenting with sternal discomfort. In a work up for metastatic disease computed tomography (CT) of the abdomen and pelvis with contrast was performed. Axial (a) and sagittal (b) images from the original CT abdomen and pelvis with contrast showing the enlarged aortocaval lymph node (arrow) in plane with the L2-L3 disc space.

{{Figure-1}}
The biopsy was performed in the CT suite with the patient positioned prone. The aortocaval lymph node was again identified on the planning CT scan and the right posterior transdiscal approach was selected for biopsy. The skin was cleaned, prepped, and draped in sterile fashion and 10 ml of 1% lidocaine was injected for local anesthetic. Under CT guidance, a 19G coaxial needle was advanced through the right posterior transdiscal approach, initially starting just lateral to the right superior articular process of L3 and advancing the needle through to the mid portion of the lateral side of the L2-L3 intervertebral disc, similar to an approach that would be used for discography. The coaxial needle was then advanced through the L2-L3 intervertebral disc to the aortocaval lymph node. Care was taken to avoid the associated neural foramina as the coaxial needle was advanced to the intervertebral disc and subsequently through the disc to the lymph node. A 20G semi-automated biopsy needle (Bard Mission, Bard Biopsy Systems, Tempe, Arizona, USA) was then advanced through the coaxial needle and core biopsy was performed (Figure 2). A total of five passes were made. The biopsy cores were placed in a formalin solution and sent to the pathology laboratory. A post-procedure CT showed no complications. The patient received 3 mg of intravenous midazolam (Versed) and 150 mcg of intravenous fentanyl for moderate sedation and pain control during the procedure. The patient was discharged home in her pre-procedural state of health an hour following the procedure. Final pathologic diagnosis confirmed metastatic carcinoma consistent with the breast primary. As per the electronic medical record, she had no procedure-associated pain in the months following the procedure. With the positive biopsy, the originally seen bone lesions we presumed to be metastases and have regressed from lytic to sclerotic lesions during chemotherapeutic treatment.
The patient provided consent for the publication of this case report including the use of the related CT images in the figures.
Fig2A.jpg Fig2B.jpg

Figure 2: A 48-year-old woman with a history of breast cancer undergoing biopsy of an enlarged aortocaval lymph node. Intraprocedural computed tomography (CT) images (a and b) with the lymph node (arrow) and relevant local anatomy (A = Aorta, D = Duodenum, I = Inferior Vena Cava) labeled demonstrate the transdiscal biopsy technique.

Fig2A.jpg
Fig2B.jpg

Figure 2: A 48-year-old woman with a history of breast cancer undergoing biopsy of an enlarged aortocaval lymph node. Intraprocedural computed tomography (CT) images (a and b) with the lymph node (arrow) and relevant local anatomy (A = Aorta, D = Duodenum, I = Inferior Vena Cava) labeled demonstrate the transdiscal biopsy technique.

{{Figure-2}}

DISCUSSION


This case report describes the transdiscal approach being safely and effectively used in core biopsy of an enlarged aortocaval lymph node in a patient with a history of breast cancer. Although the transdiscal approach has been previously described for nerve plexus block and neurolysis using 22G spinal needles, reports describing the approach in biopsy are lacking. We safely used a larger 19G coaxial needle and a 20G biopsy needle without complication. Previous reports of percutaneous biopsy in the aortocaval region had been largely relegated to fine needle aspiration due to difficulty in approach. For instance, the cases described by Gupta et al. in which a curved needle used to avoid structures negated the ability to obtain core biopsies.[6] Using the linear transdiscal approach, we were able to avoid organs, bowel, and vessels and obtain a core biopsy, which is required for the pathological evaluation of some malignancies and conditions, namely, lymphoma. Advantages and limitations of percutaneous approaches are described in Table 1. In our patient, the biopsy was positive for metastatic disease and affected the staging and management of a patient with no previously known extra-axillary lymph node metastases.
Biopsy of lymph nodes in the aortocaval region was historically a surgical endeavor through the open approach, but more recently has been performed surgically by laparoscopic or robotic techniques.[7,8] Endoscopic approaches to biopsy aortocaval lymph nodes have also been described.[9,10] Advantages and limitations of these methods for biopsy of the aortocaval region are listed along with the percutaneous approaches in Table 1.

Table 1: Advantages and limitations of methods of aortocaval region biopsy

MethodPercutaneous approachAdvantagesLimitations
Percutaneous biopsy  
  • Minimally invasive, do not require general anesthesia
 
  Anterior approach
  • Can avoid major vessels
  • Often limited to aspiration cytology due to need to traverse bowel/other structures or use curved needle
  Posterior paravertebral approach
  • Avoids organs and bowel
  • Major vessels often make lesion unapproachable
  Lateral approach
  • Can avoid bowel and organs with patient positioned prone
  • Major vessels, organs, and bowel can still be problematic despite patient positioning
  Transdiscal approach
  • Allows for avoidance of major vessels, organs, and bowel
  • Allows for linear approach for core biopsy
  • Targeted lesion must be at the level of or very near a disc space
Endoscopic  
  • Minimally invasive, does not require general anesthesia
  • Targeted lesion must be near endoscopically accessible bowel
  • Often limited to aspiration cytology
Surgical – open, laparoscopic, robotic  
  • Allows for excisional biopsy
  • Most lesions are surgically accessible
  • Most invasive methods, greatest morbidity and length of stay
  • All require general anesthesia
There are some limitations to the transdiscal approach described with most salient limitation being location of lesion near the intervertebral disc (Table 1). Additional limitations include the fact care must be taken to avoid the nerve roots and neural foramina during the procedure and previously reported relatively rare risks of discitis, disc rupture, and hematoma formation, none of which were experienced by our patient.[3]

CONCLUSION


The transdiscal approach described can be used safely and effectively for core biopsy of aortocaval lesions otherwise inaccessible for percutaneous core biopsy by standard interventional techniques.

REFERENCES


1. Erdine S, Yucel A, Celik M, Talu GK. Transdiscal approach for hypogastric plexus block. Reg Anesth Pain Med 2003;28:304-8.
PubMed      Google Scholar
2. Turker G, Basagan-Mogol E, Gurbet A, Ozturk C, Uckunkaya N, Sahin S, et al. A new technique for superior hypogastric plexus block: The posteromedian transdiscal approach. Tohoku J Exp Med 2005;206:277-81.
PubMed      Google Scholar
3. Dooley J, Beadles C, Ho KY, Sair F, Gray-Leithe L, Huh B, et al. Computed tomography-guided bilateral transdiscal superior hypogastric plexus neurolysis. Pain Med 2008;9:345-7.
CrossRef     PubMed      Google Scholar
4. Kong YG, Shin JW, Suh JH. Computed tomography (CT) simulated fluoroscopy-guided transdiscal approach in transcrural celiac plexus block. Korean J Pain 2013;26:396-400.
CrossRef     PubMed      Google Scholar
5. Cazzato RL, Garnon J, Ramamurthy N, Tsoumakidou G, Thenint MA, Koch G, et al. Transdiscal hydrodissection of the retrocrural space to optimize percutaneous imageguided cryoablation of a nodal metastasis: Case report of a novel technique. J Vasc Interv Radiol 2016;27:1463-4.
CrossRef     PubMed      Google Scholar
6. Gupta S, Ahrar K, Morello FA Jr. Wallace MJ, Madoff DC, Hicks ME, et al. Using a coaxial technique with a curved inner needle for CT-guided fine-needle aspiration biopsy. AJR Am J Roentgenol 2002;179:109-12.
CrossRef     PubMed      Google Scholar
7. Blythe JG, Edwards E, Heimbecker P. Paraaortic lymph node biopsy: A twenty-year study. Am J Obstet Gynecol 1997;176:1157-62.
PubMed      Google Scholar
8. Pakish J, Soliman PT, Frumovitz M, Westin SN, Schmeler KM, Reis RD, et al. A comparison of extraperitoneal versus transperitoneal laparoscopic or robotic para-aortic lymphadenectomy for staging of endometrial carcinoma. Gynecol Oncol 2014;132:366-71.
CrossRef     PubMed      Google Scholar
9. von Bartheld MB, Rabe KF, Annema JT. Transaortic EUS-guided FNA in the diagnosis of lung tumors and lymph nodes. Gastrointest Endosc 2009;69:345-9.
CrossRef     PubMed      Google Scholar
10. Choudhary NS, Bansal RK, Puri R, Guleria M, Sud R. Endoscopic ultrasound-guided fine-needle aspiration of an aortocaval lymph node by the transcaval approach. J Dig Endosc 2016;7:158.
CrossRef     PubMed      Google Scholar
How to cite this article:

Loftus JR, Khanna V. Transdiscal Core Biopsy of Aortocaval Lymph Node: A Case Report. Am J Interv Radiol 2017, 1(7) 1-4.



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